Level 1 evidence (終極目標:減少 Renal scarring,保全腎功能)
- BP control
- ACEi/ARB
- Sugar control
- Protein restriction
BP control: 使用ACEi/ARB及Non-DHP CCB,減少proteinuria來保腎
藉由↓Glomerular capillary hypertension
→ ↓Filtration of proteins (減少proteinuria)
→ ↓Tubular protein reabsorption
→ ↓Tubulo-interstitial inflammation
→ ↓Renal scarring
上圖修自程盟夫醫師上課講義
- Non-DHP CCB有:Verapamil、Diltiazem(Herbesser)
(會↓ Heart contratility及 conduction。HR慢、AV block、併用β-blocker者要小心使用) - ARB效果較ACEi好
結論:
- 控制血壓(用Verapamil/ Diltiazem + ACEi/ARB)
- 控制血糖
- 限制蛋白質攝取